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Transcriptional control of brown adipocyte differentiation by NFIA. NFIA binds to and activates the brown fat-specific enhancers even before differentiation. During the differentiation, NFIA facilitates the binding of PPARγ and other transcription factors, including C/EBPα, C/EBPβ and EBF2, to the brown fat-specific enhancers and promoters to control the brown fat gene programme.
