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. Author manuscript; available in PMC: 2025 Aug 25.
Published in final edited form as: Sci Transl Med. 2024 Oct 30;16(771):eabo1997. doi: 10.1126/scitranslmed.abo1997

Fig. 2. Correlation analysis of Lewy body pathology to chaperone gene expression in brains of patients with PD.

Fig. 2.

(A) Immunohistochemistry of pS129 α-synuclein (EP1536Y) in formalin fixed prefrontal cortex cortical sections detected α-synuclein-positive Lewy bodies and Lewy neurites. All scale bars represent 50 μm, except in the right-most panel scale bar = 25 μm. (B) Bar graph of Lewy body plus Lewy neurite score quantification across conditions (n = 12 with 6 PD and 6 HC, unpaired t-test P = 0.03). (C) Dot plots showing the differential expression of genes related the unfolded protein misfolding pathway in excitatory neurons (ExN) and inhibitory neurons (InN) of PD versus healthy controls (HC). (D) Dot plot of differential gene expression patterns of ExN versus InN in PD patients (log_fc: log fold changes). (E) Correlation between gene expression and pathology scores for each gene of the protein misfolding pathway. Spearman’s correlation coefficient (R2) was calculated based on normalized gene expression versus Lewy pathology score.