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Schematic illustration depicting that 12/15-LOX, cPLA2, and p38 MAPK form a positive feedback loop that amplifies inflammation in chronic cerebral hypoperfusion (CCH)-induced vascular dementia (VD). Brozopine (BZP) inhibits 12/15-LOX/cPLA2/p38 MAPK signalling in rUCCAO mice, which is largely attributed to the anti-inflammatory properties of BZP achieved via 12/15-LOX inhibition.
