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. 2025 Aug 21;32(1):2545515. doi: 10.1080/10717544.2025.2545515

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© 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 10. — Mean Shore M hardness values for matrix-type rod formulations at D0, D14/D30, and Dried: (A) excipient-free; (B) CN; (C) ZN; (D) CSP; and (E) ZAD. Error bars represent standard deviation of three replicates. The dashed line at 30 represents the Shore M hardness value of the Annovera^® vaginal ring. Shore M hardness values of all rod formulations were smaller than that of NuvaRing^® (87 units). Thus, Shore M hardness values >30 fall within the range of marketed vaginal rings. The asterisks above purple bars present significant difference levels in Shore M hardness values between B-B rod and API-B rod/between API-B and API-excipient rod at D0; asterisks above orange bars show significant differences for each rod between D0 and D14/30; while asterisks above green bars indicate differences for each rod between D0 and Dried. There.