Table 2.
Minor allele frequency, genotypes frequency, and HWE according to periodontitis in the total study sample and stratified by obesity subgroup (n = 3,554).
| Allele and genotype categories | Total | No periodontitis/stage I | Stage II | Stage III–IV |
|---|---|---|---|---|
| Total study sample, n (%) | 3,554 (100.0) | 1,479 (41.6) | 1,602 (45.1) | 473 (13.3) |
| Allele frequency G, n (%) | 3,241 (0.46) | 1,344 (0.45) | 1,484 (0.46) | 413 (0.44) |
| Allele frequency T, n (%) | 3,867 (0.54) | 1,614 (0.55) | 1,720 (0.54) | 533 (0.56) |
| Genotype frequency, n (%) | ||||
| TT | 1,054 (29.7) | 426 (28.8) | 473 (29.5) | 155 (32.8) |
| GT | 1,759 (49.5) | 762 (51.5) | 774 (48.3) | 223 (47.1) |
| GG | 741 (20.8) | 291 (19.7) | 355 (22.2) | 95 (20.1) |
| HWE, p-value | 0.887 | 0.133 | 0.255 | 0.365 |
| Stratified by obesity subgroup | ||||
| No obesity, n (%) | 2,679 (100.0) | 1,135 (42.4) | 1,214 (45.3) | 330 (12.3) |
| Allele frequency G, n (%) | 2,402 (0.45) | 1,033 (0.45) | 1,103(0.45) | 266 (0.40) |
| Allele frequency T, n (%) | 2,956 (0.55) | 1,237 (0.55) | 1,325 (0.55) | 394 (0.60) |
| Genotype frequency, n (%) | ||||
| TT | 811 (30.3) | 325 (28.6) | 370 (30.5) | 116 (35.2) |
| GT | 1,334 (49.8) | 587 (51.7) | 585 (48.2) | 162 (49.1) |
| GG | 534 (19.9) | 223 (19.6) | 259 (21.3) | 52 (15.8) |
| HWE, p-value | 0.731 | 0.149 | 0.327 | 0.714 |
| Obesity, n (%) | 875 (100.0) | 344 (39.3) | 388 (44.3) | 143 (16.3) |
| Allele frequency G, n (%) | 839 (0.48) | 311 (0.45) | 381 (0.49) | 147 (0.51) |
| Allele frequency T, n (%) | 911 (0.52) | 377 (0.55) | 395 (0.51) | 139 (0.49) |
| Genotype frequency, n (%) | ||||
| TT | 243 (27.8) | 101 (29.4) | 103 (26.5) | 39 (27.3) |
| GT | 425 (48.6) | 175 (50.9) | 189 (48.7) | 61 (42.7) |
| GG | 207 (23.7) | 68 (19.8) | 96 (24.7) | 43 (30.1) |
| HWE, p-value | 0.426 | 0.618 | 0.616 | 0.080 |
HWE: Hardy–Weinberg equilibrium