TABLE 3.

Box–Behnken design-based design of experimentation for 16 trial formulations.

Runs	X1	X2	X3	Y1	Y2	Y3
F1	300	0.5	400	418.7	0.433	80
F2	300	1	200	198.6	0.275	68.3
F3	300	1	600	718.7	0.499	85
F4	300	1.5	400	331.9	0.367	78.5
F5	600	0.5	200	310.2	0.332	77
F6	600	0.5	600	511.6	0.483	83
F7	600	1	400	227.6	0.300	72
F8	600	1	400	234.5	0.291	75
F9	600	1	400	221.9	0.312	71
F10	600	1	400	231.5	0.297	73
F11	600	1.5	200	332.5	0.376	79.8
F12	600	1.5	600	457.1	0.422	82
F13	900	0.5	400	209	0.278	69
F14	900	1	200	190.6	0.212	66.4
F15	900	1	600	227.6	0.3	70
F16	900	1.5	400	268	0.345	75.3

X1, stirring speed (RPM); X2, surfactant concentration (%); X3, polymer concentration (mg); Y1, particle size (nm); Y2, PDI; Y3, entrapment efficiency (%).