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. 2025 Aug 8;12:1578594. doi: 10.3389/fcvm.2025.1578594

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© 2025 Murphy, Le, Fedorova, Yang, Krause-Hauch, Davitt, Zoungrana, Fatmi, Lesnefsky, Li and Ren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impairs mitochondrial oxidative phosphorylation in the 5XFAD heart, hippocampus, and cortex. (A) Mitochondrial stress assay examined the mitochondrial oxidative phosphorylation (OXPHOS) complexes activity in the heart of 5XFAD (6 months) and WT (6 months) mice demonstrated by measuring the oxygen consumption rate (OCR). N = 6 for each group. For each mouse, we collected 9–10 wells using isolated cardiomyocytes for OCR measurement and averaged the results to obtain a single value per mouse. P-value determined by two-tailed students t-test. (B) Mitochondrial stress assay examined the mitochondrial oxidative phosphorylation (OXPHOS) complexes activity in the hippocampus of 5XFAD (6 months) and WT (6 months) mice demonstrated by measuring the oxygen consumption rate (OCR). N = 6 for each group. For each mouse, we collected 1–2 tissue samples for OCR measurement and averaged the results to obtain a single value per mouse. P-value determined by two-tailed students t-test. (C) Mitochondrial stress assay examined the mitochondrial oxidative phosphorylation (OXPHOS) complexes activity in the cortex of 5XFAD (6 months) and WT (6 months) mice demonstrated by measuring the oxygen consumption rate (OCR). N = 6 for each group. For each mouse, we collected 1–2 tissue samples for OCR measurement and averaged the results to obtain a single value per mouse. P-value determined by two-tailed students t-test.