Figure 5.

Aβ burden and cognitive function assessment in AD mice. (A) Representative images and quantification of Aβ stained with 6E10 antibody in the hippocampus and cortex of 5XFAD (6 months) mice and WT (6 months) mice. Biological replicates N = 8 for each group. P-value determined by two-tailed students t-test. (B) Radial arm water maze test showed the latencies to hidden platform and the errors happen in arms in WT (6 months) and 5XFAD (6 months) mice. Biological replicates N = 8 for each group. P-value determined by two-tailed students t-test. (C) Myocardial histology analysis showed elevated fibrosis in 5XFAD (6 months) mice heart compared to the WT (6 months) group. Biological replicates N = 3 for each group. For each mouse, we collected 4 tissue sections for measurement and averaged the results to obtain a single value per mouse. P-value determined by two-tailed students t-test. Black arrows highlighted the inflammatory infiltration and fibrosis formation in 5XFAD (6 months) heart H&E staining and Trichrome staining, respectively.