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. 2025 Jul 1;51(6-7):223–237. doi: 10.14745/ccdr.v51i67a02

Table 3. Estimated anti-hepatitis C virus antibodies prevalence for the general population and key populations, Canada, 2021.

Population Population size estimate Prevalence (%) Estimated number of people with current or past HCV infection Reference(s)
Point estimate Lower bound Upper bound Point estimate Lower bound Upper bound
General population 38,239,864 0.99% 0.68% 1.3% 378,000 258,000 497,000 ((12,21,2931))
Unpublished data from PHAC, 2021 (this study)
PWID, within 12 months 100,300 64.2% 36.7% 91.8% 64,400 36,800 92,100 ((3235))
Unpublished data from the Virtual Cascade of Care Cohort study, 2018–2019 (personal communication, Stine Høj, 2023)
Unpublished data from the HEPCO study, 2022–2023 (personal communication, Sarah Larney, 2024)
People who have ever injected drugs 388,400 35.4% 9.3% 61.5% 137,000 36,100 239,000 ((21,33,3537))
Unpublished data from the Virtual Cascade of Care Cohort study, 2018–2019 (personal communication, Stine Høj, 2023)
People incarcerated in provincial prisonsa 18,950 14.2% 9.5% 19.0% 2,700 1,790 3,600 ((3841))
Unpublished data from Alberta Health Services, 2023 (personal communication, Kaylee Goralcyk, 2024)
People incarcerated in federal prisonsb 12,405 11.1% 10.2% 12.0% 1,370 1,260 1,490 Unpublished data from Correctional Service Canada, 2021 (personal communication, 2024)
First Nations 1,048,400 8.0% 3.5% 12.5% 84,000 36,600 131,000 ((4244))
Unpublished data from the CHMS, Statistics Canada, 2014–2015
Immigrants from countries where hepatitis C is common (≥2% seroprevalence) 1,276,405 4.0% 2.9% 6.7% 51,500 36,700 85,300 ((25))
GBMSM 669,613 3.0% 0.82% 5.2% 20,100 5,490 34,800 ((27,45,46))
Unpublished data from the Engage cohort study, 2017–2019
Adults in the 1945–1975 birth cohort 14,267,340 1.9% 1.1% 2.7% 270,000 157,000 383,000 ((12,21,2931,36,47))
Unpublished data from PHAC, 2021 (this study)
Inuit Insufficient information
Métis Insufficient information

Abbreviations: CHMS, Canadian Health Measures Survey; HCV, hepatitis C virus; HEPCO, Hepatitis Cohort; GBMSM, gay, bisexual and other men who have sex with men; PHAC, Public Health Agency of Canada; PWID, people who inject drugs

a Who were sentenced for two years or more

b Who were sentenced for less than two years