Table 10.
Adjusted Logistic Regression Analysis of Association of Key Study Characteristics with Research Waste
| Characteristic | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Time of registration | ||||
| 2003–2013.06 | 1 | |||
| 2013.06–2023 | 0.720 (0.300–1.731) | 0.463 | ||
| Intervention | ||||
| Nonpharmacological related | 1 | |||
| Pharmacological related | 0.955 (0.371–2.455) | 0.924 | ||
| Arm | ||||
| 2 | 1 | |||
| 3 | 0.618 (0.188–2.033) | 0.429 | ||
| ≥4 | 0.275 (0.047–1.609) | 0.152 | ||
| Blinding | ||||
| None or open label | 1 | |||
| Single | 0.319 (0.041–2.465) | 0.274 | 0.335 (0.040–2.812) | 0.313 |
| Double or more | 0.200(0.045–0.892) | 0.035* | 0.193 (0.042–0.894) | 0.035* |
| Funder type | ||||
| None or departmental | 1 | |||
| Industry or other external | 1.182 (0.499–2.799) | 0.704 | ||
| Recruitment | ||||
| Single center | 1 | |||
| Multicenter | 1.046 (0.431–2.535) | 0.921 | ||
| No. of participants | ||||
| <350 | 1 | |||
| ≥350 | 0.405 (0.166–0.991) | 0.048* | 0.445(0.182–1.151) | 0.095 |
| PI region | ||||
| Nonhigh SDI | 1 | |||
| High SDI | 1.373 (0.528–3.569) | 0.516 | ||
| PI region | ||||
| <90 | 1 | |||
| ≥90 | 0.250 (0.084–0.748) | 0.013* | 0.236 (0.073–0.765) | 0.016* |
| PI region | ||||
| High income | 1 | |||
| Nonhigh income | 0.744 (0.273–2.031) | 0.564 | ||
| PI region | ||||
| North America | 1 | |||
| Europe | 0.778 (0.243–2.494) | 0.672 | ||
| Other | 0.681 (0.247–1.877) | 0.458 | ||
*
P < 0.05