Table 12.
Adjusted Logistic Regression Analysis of Association of Key Study Characteristics with Reference in Guidelines
| Characteristic | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Time of registration | ||||
| 2003–2013.06 | 1 | |||
| 2013.06–2023 | 1.007 (0.415 ~ 2.443) | 0.987 | ||
| Intervention | ||||
| Nonpharmacological related | 1 | |||
| Pharmacological related | 1.782 (0.767 ~ 4.137) | 0.179 | ||
| Blinding | ||||
| None or open label | 1 | |||
| Single | 1.528 (0.385 ~ 6.070) | 0.547 | ||
| Double or more | 0.726 (0.301 ~ 1.752) | 0.476 | ||
| Funder type | ||||
| None or departmental | 1 | |||
| Industry or other external | 1.456 (0.657 ~ 3.229) | 0.355 | ||
| Recruitment | ||||
| Single center | 1 | |||
| Multicenter | 2.763 (1.143 ~ 6.683) | 0.024* | ||
| No. of participants | ||||
| <350 | 1 | |||
| ≥350 | 1.667 (0.721 ~ 3.852) | 0.232 | ||
| PI region | ||||
| Nonhigh SDI | 1 | |||
| High SDI | 2.857 (0.897 ~ 9.096) | 0.076 | ||
| PI region | ||||
| <90 | 1 | |||
| ≥90 | 2.833 (0.990 ~ 8.109) | 0.052 | ||
| PI region | ||||
| High income | 1 | |||
| Nonhigh income | 0.469 (0.145 ~ 1.520) | 0.207 | ||
| PI region | ||||
| North America | 1 | |||
| Europe | – | 0.785 | ||
| Other | 0.865 (0.345 ~ 2.167) | 0.756 | ||
*
P < 0.05