Table 2.
Characteristics of All RCTs
| Characteristic | RCTs, NO. (%) N = 182 |
|---|---|
| Time of registration | |
| 2003–2008 | 76 (41.8) |
| 2009–2013 | 44 (24.2) |
| 2014–2018 | 29 (15.9) |
| 2019–2023 | 33 (18.1) |
| Intervention | |
| Drug | 127 (69.8) |
| Procedure | 34 (18.7) |
| Device | 12 (6.6) |
| Other | 9 (4.9) |
| Primary purpose | |
| Treatment | 158 (86.8) |
| Prevent | 1 (0.5) |
| Support care | 1 (0.5) |
| Other | 22 (12.1) |
| Intervention model | |
| Parallel | 152 (83.5) |
| Factorial | 2 (1.1) |
| Crossover | 28 (15.4) |
| Arm | |
| 2 | 151 (83.0) |
| 3 | 22 (12.1) |
| ≥4 | 6 (3.3) |
| Missing | 3 (1.6) |
| Blinding | |
| None or open label | 49 (26.9) |
| Single | 17 (9.3) |
| Double | 66 (36.3) |
| Triple | 19 (10.4) |
| Quadruple | 31 (17.0) |
| Recruitment | |
| Monocentric | 76 (41.8) |
| Multicenter | 100 (54.9) |
| Missing | 6 (3.3) |
| Funder type | |
| None or departmental | 91 (50.0) |
| Industry or other external | 91 (50.0) |
| Region of PI | |
| North America | 65 (35.7) |
| Europe | 44 (24.2) |
| Asia | 65 (35.7) |
| South America | 4 (2.2) |
| Oceania | 4 (2.2) |
| Region of PI | |
| HAQ<90 | 164 (90.1) |
| HAQ≥90 | 18 (9.9) |
| Region of PI | |
| High Income | 144 (79.1) |
| Nonhigh income | 38 (20.9) |
| Region of PI | |
| High SDI | 138 (75.8) |
| Nonhigh SDI | 44 (24.2) |