Table 2.

Association of retinal vascular features with incident aortic aneurysm and aortic adverse events

	Model 1		Model 2		Model 3
RVF	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Aortic aneurysm
Branching Angle
branchingdensity_a	0.73 (0.65, 0.83)	<0.001	0.86 (0.75, 0.97)	0.014	0.87 (0.77, 0.99)	0.036
Caliber
calibre_min_MAD_v	1.27 (1.14, 1.42)	<0.001	1.19 (1.06, 1.33)	0.003	1.15 (1.03, 1.29)	0.017
calibre_min_mean_v	1.20 (1.10, 1.32)	<0.001	1.16 (1.05, 1.27)	0.003	1.13 (1.02, 1.25)	0.025
calibre_min_median_v	1.25 (1.12, 1.40)	<0.001	1.17 (1.05, 1.31)	0.006	1.14 (1.02, 1.27)	0.027
calibre_min_std_v	1.20 (1.07, 1.33)	0.001	1.19 (1.07, 1.32)	0.001	1.15 (1.03, 1.28)	0.010
Aortic adverse events
Branching Angle
angularasymmetry_min_v	0.51 (0.32, 0.81)	0.004	0.51 (0.32, 0.80)	0.004	0.48 (0.30, 0.77)	0.002

RVF, retinal vascular feature; HR, hazard ratio; CI, confidence interval.

Model 1 is unadjusted; model 2 is adjusted for baseline age and sex; model 3 is adjusted for baseline age, sex, body mass index, smoking status, diabetes, hypertension, and hyperlipidemia.