Table 3.

Association of retinal vascular features with incident abdominal aortic aneurysm and thoracic aortic aneurysm

	Model 1		Model 2		Model 3
RVF	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Abdominal aortic aneurysm
Caliber
calibre_max_MAD_v	1.32 (1.11, 1.57)	0.002	1.29 (1.09, 1.52)	0.003	1.21 (1.02, 1.43)	0.033
Thoracic aortic aneurysm
Caliber
calibre_mean_mad_v	1.22 (1.01, 1.47)	0.043	1.24 (1.03, 1.50)	0.021	1.26 (1.04, 1.47)	0.018
calibre_mean_std_v	1.25 (1.03, 1.51)	0.024	1.27 (1.05, 1.53)	0.012	1.28 (1.06, 1.51)	0.010
calibre_min_MAD_v	1.29 (1.07, 1.55)	0.009	1.22 (1.01, 1.47)	0.042	1.26 (1.04, 1.55)	0.020
calibre_min_mean_v	1.24 (1.07, 1.44)	0.005	1.21 (1.03, 1.41)	0.018	1.21 (1.04, 1.44)	0.012
calibre_min_std_v	1.28 (1.07, 1.53)	0.008	1.27 (1.07, 1.52)	0.007	1.27 (1.07, 1.53)	0.007
Complexity
level_kurt_a	0.75 (0.61, 0.92)	0.006	0.80 (0.65, 0.98)	0.028	0.81 (0.66, 0.92)	0.048
level_skew_a	0.75 (0.62, 0.91)	0.003	0.80 (0.66, 0.97)	0.026	0.82 (0.67, 0.91)	0.043
Length
arc_kurt_a	0.73 (0.57, 0.95)	0.017	0.76 (0.59, 0.97)	0.027	0.77 (0.60, 0.95)	0.042
Tortuosity
tortuosity_MAD_v	0.81 (0.66, 0.99)	0.038	0.81 (0.66, 0.98)	0.033	0.81 (0.67, 0.99)	0.044

RVF, retinal vascular feature; HR, hazard ratio; CI, confidence interval.

Model 1 is unadjusted; model 2 is adjusted for baseline age and sex; model 3 is adjusted for baseline age, sex, body mass index, smoking status, diabetes, hypertension, hyperlipidemia, and genetic risk score of abdominal aortic aneurysm/ thoracic aortic aneurysm.