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. 2025 Aug 18;17:255–268. doi: 10.2147/OPTO.S520285

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© 2025 Triantafyllopoulos et al.

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Representative case illustrating the reclassification of (a) an Outside Normal Limits (ONL) case (without the KIROS filter) to (b) Within Normal Limits (WNL) (with the KIROS filter). (c) Optic nerve head imaging using Optical Coherence Tomography (OCT) revealed only borderline thinning of the superior retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC), which is insufficient to explain the VF defect observed without the KIROS filter. This case highlights the filter’s ability to reduce false-positive classifications or over-diagnosis, potentially improving diagnostic specificity by minimizing the impact of noise or artifacts.