Fig. 3. Functional characterization of ACMos and ADMos in hCO-MPSs.
(A) Representative images showing Aβ phagocytosis by ACMo and ADMo within hCO-MPSs. Scale bars, 10 μm. (B) Quantification of Aβ phagocytosis shown in (A) (mean ± SEM, n = 5 organoids, from three independent experiments). (C) Expression of phagocytosis- and Aβ catabolism-related genes in ACMo and ADMo within hCO-MPSs. (D) A volcano plot displaying differentially expressed genes (DEGs) in ADMo compared to ACMo within hCO-MPSs. (E) Gene ontology (GO) enrichment analysis based on ADMo DEGs.
