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. 2025 Aug 22;11(34):eadx9763. doi: 10.1126/sciadv.adx9763

Fig. 4. Suture fusion was inhibited in all Twist1+/− mice by treatment with PEG-peptide plasmid miR-200a.

Fig. 4.

(A) P21 WT mouse coronal sutures were sectioned and H&E stained to visualize the frontal and parietal bones and suture cells. The WT mouse coronal sutures are all patent (open and unfused). (B) Coronal suture fusion in untreated P21 Twist1+/− mice; note that some sections do not show fusion; however, other sections show fusion; thus, the entire suture is not completely fused. (C) Coronal suture fusion in EV-treated Twist1+/− mice; again, in these sections, the suture is fused. (D) Coronal suture patency is restored in all sections of Twist1+/− mice treated with PEG-peptide plasmid miR-200a, similar to WT mice.