Table 4. Examples of AMPK-dependent genes down-regulated in BAY-3827 in MK-8722–stimulated control hepatocytes.
The complete list of differentially expressed genes in BAY-3827 + MK-8722 versus MK-8722 in control hepatocytes is recorded in table S3.
| Gene | Name | LogFC | FDR |
|---|---|---|---|
| LIPE | Lipase, hormone sensitive | −0.28159 | 0.004450324 |
| PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | −0.54205 | 3.09 × 10−08 |
| HMGCR | 3-hydroxy-3-methylglutaryl–CoA reductase | −0.16208 | 0.00451032 |
| PLIN5 | Perilipin 5 | −1.29957 | 5.66092 × 10−18 |
| LPIN2 | Lipin 2 | −0.52774 | 1.10 × 10−08 |
| PLIN4 | Perilipin 4 | −1.23494 | 4.01982 × 10−14 |
| SP1 | trans-acting transcription factor 1 | −0.43973 | 7.4359 × 10−13 |
| HPGD | Hydroxyprostaglandin dehydrogenase 15 (NAD) | −1.745 | 5.54633 × 10−14 |
| EHHADH | Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | −1.5955 | 2.79131 × 10−17 |
| AVPR1A | Arginine vasopressin receptor 1A | −1.70797 | 7.31686 × 10−13 |
| ADORA2B | Adenosine A2b receptor | −1.3062 | 7.77511 × 10−11 |
| TBC1D15 | TBC1 domain family, member 15 | −0.48954 | 1.47094 × 10−15 |
| TBC1D17 | TBC1 domain family, member 17 | −0.559835768 | 9.72654 × 10−17 |
| HAL | Histidine ammonia lyase | −1.34842 | 1.52157 × 10−09 |