Figure 2.

Single-cell multiomics to define clonal evolution. (A) Stacked heat maps representing genotype (top), cell surface markers (middle), and Chr7 ploidy (bottom). Each column is a single analyzed cell. (B) Centered log ratio count histograms showing relative abundance of relevant cell surface markers by cell genotype. (C) Inferred clonal evolution trees using single-cell DNA-sequencing data and cellular indexing of transcriptomes and epitopes-sequencing data. Disease type and the number of cells analyzed are listed below the patient identifier. The first population (WT; purple) refers to the percentage of myeloid cells without a driving mutation or alt(7). Each following population (orange and/or green) depicts a sequential, additional modification to the initial myeloid population. Adj, Adjusted.