Figure 2.

Anatomical and schematic diagrams for the mathematical model. Top: anatomical diagram, showing the locations of the tear film (Tear), aqueous humor (Aq), and vitreous humor (Vit), together with the application of topical and intravitreal treatments (the tear film and representations of treatment are not to scale). (Top panel created in https://BioRender.com/i25q634.) Bottom: schematic diagram, summarizing the movement of v (V), r (R), u (VR), and w (RVR) between compartments; their reactions ($\rightleftharpoons$) and degradation (→ ∅) within compartments; and the dynamic tear volume, V_Tear (see Table 2 for a full list of model variables). Parameters: β_Tear-Aq,r (cm h⁻¹), the permeability of the tear-aqueous interface to R with CPP; β_Aq-Vit,j (cm h⁻¹), for j ∈ {v, r, u, w}, the permeability of the aqueous-vitreous interface to V/R/VR/RVR; ${\beta }_{\mathrm{Vit}-\mathrm{Ret},\tilde{j}}$ (cm h⁻¹), for $\tilde{j}\in \{r,u,w\}$, the permeability of the vitreo-retinal interface to R/VR/RVR; ψ_Tear (mL h⁻¹), the rate of fluid inflow/outflow to/from the tear film (causing dilution of R); ψ_Aq (mL h⁻¹), the rate of fluid inflow/outflow to/from the aqueous (causing dilution of V, R, VR, and RVR); and ϕ_Vit,v (pmol h⁻¹), the rate at which the retina contributes V to the vitreous (see Table 3 for a full list of model parameters and their values).