Table 1.
Top ten significant results of the global-corrected regional MR analyses between SA regional measures and the selected phenotypes.
| exposure | outcome | nsnps | β | 95% CI | se | p.fdr |
|---|---|---|---|---|---|---|
| insula | CP | 14 | 0.28 | 0.19 0.38 | 0.05 | 5.30 × 10−5 |
| precuneus | HDL | 22 | −0.21 | −0.28 −0.13 | 0.04 | 5.41 × 10−5 |
| parahippocampal | SmkInit | 8 | 0.37 | 0.24 0.50 | 0.07 | 5.41 × 10−5 |
| lingual | logTG | 17 | −0.22 | −0.30 −0.14 | 0.04 | 10.02 × 10−5 |
| precuneus | EA | 21 | −0.18 | −0.26 −0.11 | 0.07 | 1.83 × 10−3 |
| transverse temporal | CP | 14 | 0.24 | 0.14 0.34 | 0.05 | 1.90 × 10−3 |
| lateralorbitofrontal | SmkInit | 19 | −0.18 | −0.26 −0.10 | 0.04 | 4.48 × 10−3 |
| parahippocampal | logTG | 6 | 0.34 | 0.19 0.50 | 0.08 | 6.01 × 10−3 |
| rostralmiddlefrontal | SmkInit#2 | 16 | −0.19 | 0.01 0.03 | 0.05 | 0.03 |
| temporal pole | CDG | 1 | −0.90 | −0.28 −0.10 | 0.23 | 0.03 |
The results are ranked by significance, i.e., the FDR-corrected p-value (p.fdr). nsnps: number of the extracted genetic instruments, i.e., the independent (r2 < 0.01) SNPs, β: beta value, se: standard error. Outcomes: CP: cognitive performance, HDL: high-density lipoprotein, SmkInit: smoking initiation 2019 (ever smoking regularly 2019), logTG: log-transformed triglycerides, EA: educational attainment, SmkInit#2: smoking initiation 2022 (ever smoking regularly 2022), CDG: cross disorders group. Statistical tests were two-sided, and p-values were FDR-corrected to adjust for multiple testing.