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. Author manuscript; available in PMC: 2025 Aug 25.
Published in final edited form as: Clin Trials. 2025 Aug 21;22(6):667–675. doi: 10.1177/17407745251358233

Table 3.

Simulation results for H0:p=0.2 and H1:p=0.4 with Simon’s optimal sample size.

Data (n1, n2) Par Simon logit(0.2) logit(0.3) logit(0.4)
H0 (5, 31) p^ 0.32 (0.08) 0.21 (0.07) 0.22 (0.08) 0.22 (0.08)
FPR 0.01 0.08 0.08 0.08
PET 0.99 0.59 0.57 0.56
ESS 5.21 17.79 18.32 18.79
(15, 21) p^ 0.24 (0.07) 0.21 (0.07) 0.21 (0.07) 0.21 (0.07)
FPR 0.07 0.08 0.08 0.08
PET 0.65 0.56 0.55 0.54
ESS 22.39 24.28 24.51 24.69
(20, 16) p^ 0.23 (0.07) 0.22 (0.07) 0.22 (0.07) 0.22 (0.07)
FPR 0.09 0.09 0.09 0.09
PET 0.41 0.56 0.55 0.55
ESS 29.42 26.98 27.14 27.25
(10, 26) p^ 0.26 (0.07) 0.21 (0.07) 0.21 (0.07) 0.21 (0.07)
FPR 0.03 0.08 0.08 0.08
PET 0.88 0.58 0.57 0.56
ESS 13.14 20.95 21.27 21.57
H1 (5, 31) p^ 0.47 (0.08) 0.40 (0.09) 0.41 (0.09) 0.41 (0.09)
Power 0.09 0.84 0.84 0.85
(15, 21) p^ 0.43 (0.08) 0.40 (0.09) 0.40 (0.09) 0.40 (0.09)
Power 0.60 0.89 0.89 0.90
(20, 16) p^ 0.41 (0.08) 0.40 (0.09) 0.40 (0.09) 0.40 (0.09)
Power 0.85 0.90 0.90 0.90
(10, 26) p^ 0.40 (0.08) 0.40 (0.09) 0.40 (0.09) 0.40 (0.09)
Power 0.89 0.90 0.90 0.90

FPR = false positive rate; PET = probability of early termination; ESS=expected sample size