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. Author manuscript; available in PMC: 2026 Jan 24.
Published in final edited form as: Cell Stem Cell. 2025 Aug 14;32(9):1421–1437.e6. doi: 10.1016/j.stem.2025.07.010

Figure 3: The fibroblast epigenomic landscape of skin reveals a transition to an open landscape in the remodeling phase compared to the fibrotic phase.

Figure 3:

(A) UMAP of chromatin accessibility-based cell types identified via scATAC-seq. (B) Accessibility of characteristic fibroblast genes on scATAC-seq clusters. (C) UMAP of chromatin accessibility-based fibroblast clusters identified via scATAC-seq. (D) Coverage plots of top differentially accessible peaks with gene annotations for fibroblasts. (E) Gene ontology pathways (Top) and terms (Bottom) associated with fibroblasts at Day 0 (Left), Day 21 (Middle) and Day 28 (Right). (F) Highly enriched DNA motifs for fibroblasts comparing different timepoints. Red font indicates timepoint of enrichment. (G) Immunostaining of DNA motifs at Day 21 (top) and day 28 (bottom) identified through scATAC-seq. White arrows show positive staining. Scale bar (G) 150 μm.