Table 1.
Comparisons of demographic variables, cognitive scores and APOE ε4 proportions between IA– and IA+
| IA– | IA+ | |
|---|---|---|
| N (%) | 85 (89.47) | 10 (10.53) |
| Demographics, cognitive, and genetic features | ||
| Age, years | 68.63 (9.13) | 68.89 (8.61) |
| Disease duration, years | 6.24 (6.3) | 8.59 (7.4) |
| Gender, women/men | 55 (64.70%) | 6 (60.0%) |
| Family history of dementia | 50 (58.82%) | 6 (60.0%) |
| Years of education | 12.33 (4.19) | 11.78 (3.49) |
| APOE ε4+ | 35 (41.18%) | 5 (50.0%) |
| MMSE | 26.33 (2.37) | 26.38 (1.87) |
| AD biomarker concentrations | ||
| Aβ42 (pg/mL) | 937.55 (444.02) | 977.60 (480.59) |
| Aβ42/Aβ40 | 0.07 (0.03) | 0.08 (0.03) |
| p-tau (pg/mL) | 72.63 (50.88) | 63.80 (37.08) |
| t-tau (pg/mL) | 491.69 (305.17) | 480.80 (194.91) |
| NfL (pg/mL) | 18.16 (8.17) | 17.92 (12.52) |
| 18F-FDG uptakes | ||
| Middle frontal gyrus | 0.79 (0.07) | 0.81 (0.06) |
| Medial frontal gyrus | 0.77 (0.08) | 0.80 (0.069) |
| Superior frontal gyrus | 0.66 (0.10) | 0.64 (0.089 |
| Fusiform gyrus | 1.07 (0.05) | 1.04 (0.07) |
| Parahippocampal gyrus | 0.95 (0.05) | 0.94 (0.06) |
Values quoted in the table are means (SD), percentages (95% C.I.) or frequencies. Age, age at onset, and disease duration are expressed in years
IA intermediate allele, APOE Apolipoprotein E, MMSE Minimental State Examination