Table 2.
Comparisons of demographic variables, cognitive scores and genetic features between A +/T + and isolated Aβ/non-AD
| A +/T + | Isolated Aβ/non-AD | |
|---|---|---|
| N (%) | 39 (41.05) | 56 (48.95) |
| Demographics, cognitive, and genetic features | ||
| CAG repeats, short allele | 18.00 (2.00) | 18.00 (1.00) |
| CAG repeats, long allele | 22.00 (3.00) | 22.00 (4.00) |
| IA+ | 10.26 (0.73: 19.78) | 10.71 (2.61: 18.82) |
| Age, years | 72.79 (6.05)a | 65.79 (9.67)a |
| Disease duration, years | 5.56 (5.92) | 7.11 (6.74) |
| Gender, women/men | 25/14 | 36/20 |
| Family history of dementia | 51.28 (35.59: 66.97) | 44.64(31.62: 57.66) |
| Years of education | 12.50 (4.12) | 12.13 (4.15) |
| APOE ε4+ | 61.54 (46.27: 76.81)b | 29.09 (17.09: 41.09)b |
| MMSE | 25.79 (2.58) | 26.69 (2.09) |
| AD biomarker concentrations | ||
| Aβ42 (pg/mL) | 675.10 (253.07)c | 1127.48 (457.57)c |
| Aβ42/Aβ40 | 0.46 (0.01)d | 0.09 (0.02)d |
| p-tau (pg/mL) | 115.36 (46.05)e | 41.28 (20.79)e |
| t-tau (pg/mL) | 717.69 (267.37)f | 332.35 (192.38)f |
| NfL (pg/mL) | 22.98 (9.26)g | 14.54 (6.19)g |
| 18F–FDG uptakes | ||
| Middle frontal gyrus | 0.80 (0.06) | 0.80 (0.08) |
| Medial frontal gyrus | 0.77 (0.07) | 0.77 (0.09) |
| Superior frontal gyrus | 0.65 (0.11) | 0.67 (0.07) |
| Fusiform gyrus | 1.06 (0.06) | 1.07 (0.05) |
| Parahippocampal gyrus | 0.95 (0.05) | 0.94 (0.06) |
Values quoted in the table are mean (SD) for continuous variables and frequencies or percentages for dichotomic variables. CAG repeats are expressed as median (IQR). Statistical significance received a Bonferroni adjustment and being accepted at p < 0.002 for continuous variables and p < 0.012 for categorical variables
IA intermediate allele, APOE Apolipoprotein E, MMSE Minimental State Examination
ap < 0.001, d = 0.87; χ2 = 9.82
b p < 0.001, V = 0.323
c p < 0.001, d = 1.22
d p < 0.001, d = 23.40
e p < 0.001, d = 2.07
f p < 0.001, d = 1.65
g p < 0.001, d = 1.07