Table 4.
Multivariate quadratic models
| B | p | 95% CI (min:max) | ||
|---|---|---|---|---|
| Dependent variable: plasma NfL | ||||
| A+/T+ | ||||
| Diagnosis (SCD/MC) | −39.25 | 0.097 | −86.085: 7.588 | |
| Age | 0.02 | 0.517 | −0.043: 0.084 | |
| CAG repeats | 0.35 | 0.007 | 0.101: 0.600 | |
| F [5, 31] = 2.99, adj. R2 = 0.17, p = 0.025, AIC = 266.2 | ||||
| Dependent variable: middle frontal gyrus | ||||
| Isolated Aβ/non-AD | ||||
| Diagnosis (SCD/MC) | −0.22 | 0.002 | −0.358: −0.085 | |
| Age | −0.000 | 0.778 | −0.000:0.000 | |
| CAG repeats | 0.001 | 0.005 | 0.000:0.002 | |
| F [5, 42] = 2.73, adj. R2 = 0.155, p = 0.032 | ||||
| Dependent variable: medial frontal gyrus | ||||
| A+/T+ | ||||
| Diagnosis (SCD/MC) | 0.42 | 0.068 | −0.033: 0.877 | |
| Age | −0.000 | 0.340 | −0.001: 0.000 | |
| CAG repeats | −0.003 | 0.004 | −0.006: −0.001 | |
| F [5, 28] = 4.45, adj. R2 = 0.344, p = 0.004 | ||||
| Isolated Aβ/non-AD | ||||
| Diagnosis (SCD/MC) | −0.42 | < 0.001 | −0.557: −0.300 | |
| Age | 0.000 | 0.006 | 0.000: 0.000 | |
| CAG repeats | 0.002 | < 0.001 | 0.001: 0.003 | |
| F [5, 42] = 6.86, adj. R2 = 0.384, p < 0.001 | ||||
| Parahippocampal gyrus | ||||
| A+/T+ | ||||
| Diagnosis (SCD/MC) | −0.65 | < 0.001 | −0.929: −0.374 | |
| Age | 0.000 | 0.024 | 0.000: 0.001 | |
| CAG repeats | 0.002 | 0.001 | 0.001: 0.004 | |
| F [5, 28] = 6.13, adj. R2 = 0.438, p < 0.001 | ||||
Regression coefficients (B), p-values (p), and 95% confidence intervals (95% CI) for the covariates included in the model, along with model metrics (F-statistics with degrees of freedom, adjusted R2, and p-values), are reported. Statistical significance is set at p < 0.05