Table 10.
Primary outcome – Soft tissue healing
| Comparison* | Number of sites (primary studies) | Measure of effect | Effect model | Direction of effect | Follow up | Heterogeneity |
|---|---|---|---|---|---|---|
| PRF vs Spontaneous healing | 60 vs 60 (2) | SMD= –0.20; 95% CI (–1.82, 1.43) | Random | No difference | 1 day | I2= 94.7% |
| PRF vs Spontaneous healing | 70 vs 70 (3) | SMD= 0.10; 95% CI (–1.38, 1.58) | Random | No difference | 3 days | I2=93.6% |
| PRF vs Spontaneous healing | 115 vs 115 (5) | SMD= –0.03; 95% CI (–1.18, 1.13) | Random | No difference | 7 days | I2=93.7% |
| PRF vs Spontaneous healing | 90 vs 90 (4) | SMD= 0.08; 95% CI (–1.26, 1.41) | Random | No difference | 14 days | I2=93.6% |
| L-PRF vs Spontaneous healing | 50 vs 50 (2) | SMD = –0.70; 95% CI (–3.50, 2.10) | Random | No difference | 7 days | I2 =97% |
| APC vs Spontaneous healing | 78 vs 63 (3) | MD= 1.01; 95% CI (0.77, 1.24) | Fixed | Favors APC | 7 days | I2=77% |
PRF platelet rich fibrin, L-PRF leukocyte - platelet rich fibrin, APC autologous platelet concentrate, SMD standardized mean difference, MD mean difference, CI confidence interval
*Outcome measure: Landry’s healing index, Modified Landry’s healing index