Table 11.
Primary outcome – Alveolar Bone Level
| Comparison | Outcome Measure | Number of sites (primary studies) | Measure of effect | Effect model | Direction of effect | Follow up | Heterogeneity |
|---|---|---|---|---|---|---|---|
|
PRF vs Spontaneous healing |
Scintigraphic evaluation of osteoblastic activity | 34 vs 34 (2) | WMD = 0.05; 95% CI (− 0.44, 0.55) | Fixed | No difference | 28–90 days | I2=0 |
|
Regenerative techniques* vs Spontaneous healing |
Radiographic evaluation of bone height | 188 vs 188 (8) | MD= 1.21; 95% CI (0.21, 2.21) | Random | Favors regenerative techniques | 6–12 months | I2=92.7% |
|
APC vs Spontaneous healing |
Histomorphometric characteristics of the percentage of new bone | 27 vs 11 (2) | MD= 1.55%; 95% CI (–6.37, 9.48) | Fixed | No difference | 12 weeks | I2=64% |
|
APC vs Spontaneous healing |
Bone density evaluation | 50 vs 50 (2) | MD= 5.06; 95% CI (1.45, 8.66) | Fixed | Favors APC | 1 month | I2=68% |
|
APC vs Spontaneous healing |
Bone density evaluation | 50 vs 50 (2) | MD= 6.66; 95% CI (3.11, 10.21) | Fixed | Favors APC | 3 months | I2=35% |
| APC vs Spontaneous healing | Bone density evaluation | 50 vs 50 (2) | MD= 7.29; 95% CI (4.31, 10.28) | Fixed | Favors APC | 6 months | I2=0 |
|
PRF vs Spontaneous healing |
Bone density evaluation | 120 vs 120 (3) | SMD= 2.34; 95% CI (0.18, 4.51) | Random | Favors PRF | 4 months | I2= 97.2% |
APC autologous platelet concentrate, PRF platelet rich fibrin, MD mean difference, SMD standardized mean difference, CI confidence interval
*Guided tissue regeneration, Osseous grafting, Guided bone regeneration