Table 8.

Secondary outcome – Adverse Events – Alveolar Osteitis

Comparison	Number of sites (primary studies)	Number of events (primary studies)	Measure of effect	Effect model	Direction of effect	Heterogeneity
Envelope vs triangular flap	313 vs 316 (7)	42 vs 28 (7)	RR= 1.51; 95% CI (0.97, 2.35)	Fixed	No difference	I2=45%
APC vs Control	264 vs 234 (4)	8 vs 33 (4)	RR= 0.20; 95% CI (0.03, 1.18)	Random	No difference	I2= 63%
PRF vs Control	301 vs 301 (6)	25 vs 60 (6)	RR= 0.43; 95% CI (0.28, 0.65)	Fixed	Favors PRF	I2=0

APC autologous platelet concentrate, PRF platelet rich fibrin, RR risk ratio, CI confidence interval