Table 9.
Secondary outcome – Adverse Events – Swelling
| Comparison* | Number of sites (primary studies) | Measure of effect | Effect model | Direction of effect | Follow up | Heterogeneity |
|---|---|---|---|---|---|---|
| Envelope vs triangular flap | 103 vs 104 (4) |
SMD= 0.83; 95% CI (–0.48, 2.14) |
Random | No difference | 2 days | I2= 94% |
| Envelope vs triangular flap | 68 vs 68 (3) |
SMD= 0.35; 95% CI (–0.15, 0.84) |
Random | No difference | 3 days | I2= 51% |
| Envelope vs triangular flap | 139 vs 140 (6) |
SMD= 0.07; 95% CI (–0.23, 0.37) |
Random | No difference | 7 days | I2= 35% |
| Envelope vs triangular flap | 39 vs 39 (2) |
SMD= –0.09; 95% CI (–0.54, 0.35) |
Fixed | No difference | 14 days | I2= 0 |
|
HyA application vs Spontaneous Healing |
34 vs 34 (2) |
MD= –2.08; 95% CI (–23.73, 19.58) |
Random | No difference | 2–3 days | I2= 87.94% |
|
HyA application vs Spontaneous Healing |
34 vs 34 (2) |
MD= 1.75; 95% CI (–14.38, 17.89) |
Random | No difference | 7 days | I2= 66.86% |
|
PRF vs Spontaneous Healing |
412 vs 412 (11) |
MD= –1.17; 95% CI (–1.83, –0.51) |
Random | Favors PRF | 1 day | I2= 91.7% |
|
PRF vs Spontaneous Healing |
422 vs 422 (12) |
MD= –1.66; 95% CI (–2.43, –0.90) |
Random | Favors PRF | 3 days | I2=93.2% |
|
PRF vs Spontaneous Healing |
422 vs 422 (9) |
MD= –1.82; 95% CI (–2.72, –0.92) |
Random | Favors PRF | 7 days | I2=94.9% |
SMD standardized mean difference, HyA hyaluronic acid, MD mean difference, PRF platelet rich fibrin, CI confidence interval
*Outcome measure: Distance between facial reference points