Table 4.

Diagnostic accuracy of MiRNA panels for MASLD patients

miRNA panels
MASLD	AUROC	References
miR-18a/miR-16; miR-25-3p/miR-16; miR-18a/miR-21-5p; miR-18a/miR-92a-3p	0.88	[41]
miR-1290, miR-27b-3p, miR-192-5p, miR-99a-5p, miR-148a-3p, Mir-122-5P	0.85	[59]
miR33b, miR1220	0.85	[75]
WC, ALT, glycemia, miR-331	0.80	[78]
miR-126-5p, miR-15b-3p and BMI	0.68	[89]
miR29b-3p, miR-122-5p, miR151a-3p and BMI	0.85	[89]
miR21-5p, miR151a-3p and BMI	0.85	[89]
∆ Liver stiffness, ∆ Chemerin, ∆ depressive symptoms, ∆ miR-122-5p and ∆ BMI	0.86	[90]
∆ Hepatic fat content (%), ∆ TC, ∆ TG, ∆ miR-15b-3p and ∆ BMI	0.89	[90]
MASH	AUROC	References
miR-21-5p, miR-151a-3p, miR-192-5p, and miR-4449	0.87	[30]
MiR-122, miR-192, miR-21	0.81	[81]
miR-122, miR-192, miR-21, CK18-Asp396	0.83	[81]
HCC	AUROC	References
miR-34a, miR-221 miR-16, miR-23-3p, miR-122-5p, miR-198, miR-199a-3p (diabetic liver cirrhosis)	0.99	[20]
miR-34a, miR-221 miR-16, miR-23-3p, miR-122-5p, miR-198, miR-199a-3p (diabetic nonmalignant)	0.96	[20]
miR-181a + FIB-4	0.75	[77]
Let-7f-5p, miRNA-122-5p, miRNA-142-5p, miRNA-29a-3p, miRNA-451a	0.75	[79]
miR-122, miR-192, miR-375	0.70	[106]

Abbreviations: MASLD, Metabolic Dysfunction-Associated Steatotic Liver Disease; MASH, Metabolic Dysfunction-Associated Steatohepatitis; HCC, Hepatocellular Carcinoma; AUROC, Area Under the Receiver Operating Characteristic curve; WC, Waist Circumference; ALT, Alanine Aminotransferase; miRNA, microRNA; TC, Total Cholesterol; TG, Triglycerides