Table 2.

Domain-based risk of bias assessment (RoB-2) for randomized controlled trials included in the review

	D1	D2	D3	D4	D5	Overall
Cuchi et al. 2017	-	+	-	+	+	-
Cochi et al. 2021	+	+	-	+	+	-
Torres et al. 2010	+	+	+	+	+	+

D1: Bias arising from the randomization process; D2: Bias due to deviation from intended intervention; D3: Bias due to missing outcome data; D4: Bias in measurement of the outcome; D5: Bias in selection of the reported results; “+” Low risk; “-” some concerns