The diffusion of electronic nicotine delivery systems (ENDS) worldwide raises new possibilities and doubts about their impact on people’s health.

This article offers an overview of the opportunity to favor smoking cessation through ENDS use compared to traditional nicotine replacement therapy (NRT).

The utility of ENDS must be weighed against the still unknown possible long-term adverse effects of these new devices on patients’ health.

The topic is still highly debated, as can be seen from the differences in opinions between the main scientific associations regarding this issue.