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. 2025 Aug 22;12(1):88. doi: 10.1186/s40643-025-00929-x

Table 1.

Advantages and disadvantages of lignin valorization methods

valorization techniques Feedstock Advantages Disadvantages Biomass source and lignin recovery References
Biomass (Lignin%) Extraction yield (%)
Alkaline hydrolysis Agricultural residuals: Rice straw, wheat straw, sunflower stalk Operates under lower temperatures Requires an expensive catalyst and the formation of inhibitors De-oiled Jatropha waste (40–50%) 93.4% Novakovic et al. 2021; Oruganti et al. 2024
Acid hydrolysis (dilute) Wheat straw Acid recycling is not required High temperature and pressure are needed Corn stover (17–21%) 75.7% Gill et al. 2021; Sheng et al. 2022; Tu and Hallett 2019
Acid hydrolysis (concentrated) Wheat straw and bagasse Operates under mild temperatures Acid recovery is expensive and requires corrosion-free equipment Sugar cane (23.7%) 91% Ávila and Rosana 2022; Momayez et al. 2022
Oxidative cleavage Wheat straw, bagasse, and poplar sawdust Effective lignin degradation Expensive reagent requirement Toonna sinensis branches (13%) 77% Lin et al. 2024; Wei et al. 2021
Ionic liquid-assisted depolymerization Wheat straw, bagasse and peanut Sufficient dissolution Expensive ionic liquids are required in higher amounts Miscanthus x giganteus (17–25%) 82% Radhakrishnan et al. 2021; Taylor et al. 2024; Wang and Eika 2020
Pyrolysis Various lignin sources, such as dry impregnated lignin and agricultural residues Simple and less-expensive Higher temperature is required for the initiation of decomposition, which results in reduced yield of bio-oil Tobacco waste (18.6%) 85% Lu and Gu 2022; Tan et al. 2024; Wang et al. 2023
Microbial depolymerization by fungi Rice straw, wheat straw, and softwood Moderate conditions and minimal energy are sufficient, cost-effective A wide sterile area, low hydrolysis rate, and more time are required Sugarcane baggase (20–30%) 87.6% Dong et al. 2013; Giri and Sharma 2020; Hermosilla et al. 2018
Microbial depolymerization by bacteria Rice straw, wheat straw, and softwood Moderate conditions are sufficient, cost-effective Paper mill waste 89% Gu et al. 2024; Hemati et al. 2023; Kumar et al. 2022; Nurika et al. 2022
Enzymatic depolymerization Rice straw, wheat straw, and softwood Moderate conditions and minimal energy are sufficient Paper mill waste 90% Kumar et al. 2022; Weiss et al. 2020; Zhang et al. 2021