Table 1.

Comparative sensitivity & specificity on mNGS vs. traditional diagnostic Methods

Diagnostic Method	Sensitivity	Specificity	Detection Time	Pathogen Coverage	Reference
Traditional Blood Culture	40–60%	High	Days to Weeks	Bacteria, Limited	[102]
PCR	70–80%	High	Hours to Days	Targeted Pathogens	[102, 103]
mNGS	90–95%	High	24–48 Hours	Comprehensive	[104]