Table 4.

Univariate and multivariate analysis of genotypes comparison between groups

Univariate und bivariate Analyse der Genotypen zum Vergleich zwischen den Gruppen

Gene	SNP	Model	Genotype	Orthognathic mandible		Retruded mandible		p-valueu	p-valuem	PR	95% CI
				n	%	n	%
EGF	rs4444903	Co-Dominant	AA	8	18.18	33	45.83	Reference
			AG	30	68.18	34	47.22	0.004*	0.011*	0.69	0.52–0.91
			GG	6	13.64	5	6.94	0.020*	0.216	0.64	0.32–1.28
		Dominant	AA	8	18.18	33	45.83	Reference
			AG + GG	36	81.82	39	54.17	0.003*	0.008*	0.68	0.52–0.90
		Recessive	AA + AG	38	86.36	67	93.06	Reference
			GG	6	13.64	5	6.94	0.232	0.533	0.80	0.40–1.59
	rs2237051	Co-Dominant	GG	9	20.45	29	42.03	Reference
			GA	27	61.36	28	40.58	0.013*	0.006*	0.65	0.47–0.88
			AA	8	18.18	12	17.39	0.194	0.278	0.80	0.53–1.19
		Dominant	GG	9	20.45	29	42.03	Reference
			GA + AA	35	79.55	40	57.97	0.017*	0.007*	0.69	0.52–0.90
		Recessive	GG + GA	36	81.82	57	82.61	Reference
			AA	8	18.18	12	17.39	0.914	0.941	1.01	0.68–1.50
EGFR	rs2227983	Co-Dominant	GG	16	36.36	41	57.75	Reference
			GA	25	56.82	24	33.80	0.015*	0.019*	0.67	0.48–0.93
			AA	3	6.82	6	8.45	> 0.999f	0.818	0.94	0.58–1.52
		Dominant	GG	16	36.36	41	57.75	Reference
			GA + AA	28	63.64	30	42.25	0.003f*	0.028*	0.71	0.53–0.96
		Recessive	GG + GA	41	93.18	65	91.55	Reference
			AA	3	6.82	6	8.45	> 0.999f	0.650	1.11	0.69–1.79
	rs763317	Co-Dominant	AA	11	24.44	22	30.56	Reference
			AG	22	48.89	39	54.17	0.791	0.328	0.85	0.62–1.17
			GG	12	26.67	11	15.28	0.158	0.056	0.60	0.36–1.01
		Dominant	AA	11	24.44	22	30.56	Reference
			AG + GG	34	75.56	50	69.44	0.474	0.130	0.78	0.57–1.07
		Recessive	AA + AG	33	73.33	61	84.72	Reference
			GG	12	26.67	11	15.28	0.131	0.103	0.67	0.41–1.08

Frequencies between the major alleles were compared by chi-square test and between the expected number of haplotypes by Fisher exact test

EGF epidermal growth factor, EGFR epidermal growth factor receptor

*p < 0.05