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. 2025 Aug 22;8(11):e202503316. doi: 10.26508/lsa.202503316

Figure 6. Model of PRMT5 function in Merkel cell carcinoma and in limiting DNA damage.

Figure 6.

(A) PRMT5 promotes exon inclusion to maintain full-length Tip60, sustaining activity of the ST-MYCL-EP400 complex, a major driver of Merkel cell carcinoma tumorigenesis. (B) PRMT5 methylates SRSF proteins, enhancing their recruitment to m6A-marked RNA near splice sites that can coincide with R-loops. This PRMT5-SRSF axis ensures proper splicing and promotes R-loop resolution, thereby reducing replication stress and limiting DNA damage.