Table 1.

Genes of interest from Tip60-EP400 protein complex with a summary of differential expression results and isoform categories.

Gene	log2FoldChange	Padj	Isoforms	Significant_up	Significant_down	Summary_category
KAT5*	−0.41076	0.00022547	13	0	2	Truncated transcript|Canonical isoform|Alternative splicing|Other
EP400*	−0.28062	0.03810907	1	0	0	Other
TRRAP	−0.13833	0.41436348	4	0	0	Other
BRD8	0.15795	0.35760197	15	1	0	Truncated transcript|Canonical isoform|Other
EPC1	0.16909	0.13996817	6	1	0	Truncated transcript|Canonical isoform|Alternative splicing
EPC2	0.06437	0.70123456	4	0	0	Truncated transcript
MBTD1	−0.18101	0.07057304	2	0	0	Truncated transcript|Novel isoform
DMAP1	−0.14545	0.27985282	13	0	2	Alternative splicing|Truncated transcript|Canonical isoform|Other|Novel isoform
ING3	0.02489	0.92318757	8	1	1	Canonical isoform|Alternative splicing
VPS72	−0.10319	0.65086163	13	2	1	Truncated transcript|Other|Alternative splicing|Novel isoform
RUVBL2	0.11101	0.36815264	15	0	0	Alternative splicing|Truncated transcript|Canonical isoform|Other|Novel isoform
RUVBL1*	0.40189	0.00028326	14	0	0	Alternative splicing|Truncated transcript|Canonical isoform|Other|Novel isoform
ACTL6A	0.13178	0.23843247	13	0	0	Truncated transcript|Canonical isoform|Alternative splicing|Other
ACTB	0.15825	0.06197625	33	1	0	Truncated transcript|Canonical isoform|Alternative splicing|Novel isoform
MORF4L1	0.23859	0.08291186	33	0	0	Truncated transcript|Alternative splicing|Other|Novel isoform
MORF4L2*	−0.59104	1.92 × 10−11	18	2	4	Alternative splicing|Truncated transcript|Canonical isoform|Other|Novel isoform
YEATS4	−0.04442	0.78374579	7	1	2	Truncated transcript|Alternative splicing|Other|Novel isoform
MRGBP	0.17219	0.41749438	3	0	0	Truncated transcript|Alternative splicing|Other
MEAF6	0.11359	0.36804976	31	2	7	Truncated transcript|Canonical isoform|Alternative splicing|Other
H2AZ1	0.04005	0.85645869	10	0	0	​
MYCL*	0.37867	3.24 × 10−9	15	0	0	Canonical isoform|Other|Alternative splicing|Novel isoform

Log₂FoldChange and adjusted P-values are from differential expression analysis of Illumina short-read data. The number of isoforms was obtained using PacBio full-length isoform sequencing with structural categories based on the SQANTI isoform classification system. * Genes marked with an asterisk are subunits of the ST-MYCL-EP400 complex whose expression was significantly altered upon PRMT5 inhibition.