Table 2.
Comparison of cerebral nuclei volumes between TD, ET, and HC
| Feature | TDa (n = 69) | ETb (n = 71) | HCc (n = 80) | Test statistics | P valueadj | Post-hoc testd |
|---|---|---|---|---|---|---|
| Pallidum | 4041.28 ± 431.14 | 3775.04 ± 462.91 | 3763.51 ± 471.75 | 10.98 | <0.001 | a > c***, a > b** |
| L. Pallidum | 2049.19 ± 239.42 | 1899.35 ± 247.02 | 1898.06 ± 231.29 | 12.28 | <0.001 | a > c***, a > b** |
| R. Pallidum | 1992.08 ± 225.34 | 1875.69 ± 239.46 | 1865.46 ± 257.89 | 7.37 | 0.005 | a > c** |
| B. Thalamus | 14337.29 ± 1544.54 | 13330.65 ± 1913.97 | 14007.49 ± 1300.8 | 10.12 | <0.001 | a > b** |
| L. Thalamus | 7222.82 ± 781.16 | 6759.68 ± 1002.81 | 7004.12 ± 699.08 | 7.74 | 0.005 | a > b* |
| R. Thalamus | 7114.47 ± 824.69 | 6570.97 ± 947.49 | 7003.37 ± 648.91 | 11.58 | <0.001 | a > b**, b < c** |
| CC. Anterior | 894.83 ± 119.98 | 822.01 ± 154.21 | 831.38 ± 135.78 | 6.04 | 0.013 | a > b*, a > c* |
| CC. Mid Anterior | 561.33 ± 148.74 | 506.86 ± 128.24 | 504.94 ± 105.96 | 5.23 | 0.020 | a > c* |
| B. VentralDC | 7690.48 ± 766.3 | 7265.86 ± 839.84 | 7537.64 ± 746.14 | 7.98 | 0.005 | a > b* |
| L. VentralDC | 3852.87 ± 398.57 | 3641.83 ± 413.55 | 3787.08 ± 386.48 | 7.63 | 0.005 | a > b* |
| R. VentralDC | 3837.61 ± 393.83 | 3624.03 ± 442.7 | 3750.57 ± 377.24 | 7.22 | 0.005 | a > b* |
| WM. hypointensities | 2604.1 ± 2553.11 | 3175.72 ± 4371.85 | 1463.77 ± 987.71 | 7.34 | 0.005 | b > c** |
| Brain Stem | 21416.03 ± 2378.05 | 20052.45 ± 2645.77 | 20816.15 ± 2152.8 | 7.27 | 0.005 | a > b* |
| Amygdala | 1527.89 ± 217.76 | 1497.29 ± 244.46 | 1597.2 ± 214.15 | 5.88 | 0.014 | a < c* |
| B. Cerebellum Cortex | 101448.11 ± 9758.1 | 98549.25 ± 11812.63 | 102938.32 ± 9006.98 | 4.54 | 0.027 | b < c* |
| Cerebellum Cortex | 51305.13 ± 5074.38 | 49677.06 ± 6036.96 | 52236.99 ± 4618.99 | 5.76 | 0.014 | b < c* |
| B. Inf Lat Vent | 1155.31 ± 597.25 | 1257.03 ± 807.95 | 956.47 ± 533.16 | 5.49 | 0.017 | b > c* |
| R. Inf Lat Vent | 558.45 ± 319.44 | 648.73 ± 471.98 | 478.95 ± 266.1 | 5.11 | 0.020 | b > c* |
| 3rd Ventricle | 1553.73 ± 529.14 | 1652.7 ± 627.74 | 1413.37 ± 529.57 | 4.93 | 0.022 | b > c* |
| CSF | 1201.75 ± 272.39 | 1271.48 ± 379.47 | 1128.54 ± 247.32 | 4.90 | 0.022 | b > c* |
| R. Choroid plexus | 711.79 ± 190.14 | 776.23 ± 228.4 | 683.37 ± 222.47 | 4.37 | 0.030 | b > c* |
Data was shown as mean ± standard error. Analysis of covariance was performed to observe differences among groups. For regional analyses, multiple comparisons across the regions were adjusted by the false discovery rate (FDR) method. Test statistics of F were labeled.
B both, R right, L left, adj adjusted.
aTD tremor-dominant Parkinson’s disease.
bET Essential tremor.
cHC Healthy controls.
dPost-hoc pairwise comparisons were adjusted by the Bonferroni method.
*p < 0.05; **p < 0.01; ***p < 0.001.