Table 3.
Fifteen analogs of Licoflavone C were tested with their inhibitory effects on both CEN activity and SFTSV infection.
| Name | Structure | IC50 (µM) | EC50 (µM) | CC50 (µM) | SI | Name | Structure | IC50 (µM) | EC50 (µM) | CC50 (µM) | SI |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Licoflavone C |  |
35.50 | 1.85 | >300.00 | >162.16 | Licoisoflavone A |  |
94.15 | 5.00 | 40.60 | 8.12 |
| Sophoraflavanone G |  |
11.20 | 0.96 | 6.74 | 7.02 | Sophoranone |  |
122.60 | 4.00 | 15.80 | 3.95 |
| Licoflavonol |  |
16.36 | 6.86 | 42.97 | 6.26 | Luteolin |  |
133.20 | 4.32 | 90.80 | 21.02 |
| Mulberrin |  |
18.80 | 1.53 | 31.80 | 20.78 | Glabrol |  |
162.30 | 1.69 | 28.65 | 16.95 |
| Kushenol A |  |
19.63 | 2.34 | 13.62 | 5.82 | Isobavachin |  |
221.10 | 8.00 | 102.80 | 12.85 |
| Glycyrrhisoflavone |  |
46.45 | 32.00 | 124.40 | 3.89 | Leachianone G |  |
300.20 | 6.90 | 99.60 | 14.43 |
| Licoflavone A |  |
65.76 | 2.48 | 46.90 | 18.91 | Broussoflavonol F |  |
318.80 | 10.70 | 164.80 | 15.40 |
| Licoflavone B |  |
81.04 | 1.22 | 17.90 | 14.67 | Isoxanthohumol |  |
394.90 | 9.60 | 192.50 | 20.05 |
Their cytotoxicity was tested on Vero cells. IC50s, EC50s, and CC50s were listed in the order of IC50.