Table 6.
Exposure to two or more psychotropic drugs with CYP2D6 inhibition during pregnancy impaired neonatal short-term outcomes.
| CYP2D6 inhibition (+) N = 46 |
CYP2D6 inhibition (-) N = 45 |
P-value | |
|---|---|---|---|
| Birth Weight (g) | 2940 (2154–3902) | 3060 (2400–4102) | 0.06 |
| LFD | 6 (13%) | 8 (18%) | 0.27 |
| SGA | 4 (8.7%) | 2 (4.4%) | 0.21 |
| Apgar score at 1 min | 8 (1–8) | 8 (1–10) | 0.0165* |
| Apgar score at 5 min | 8 (4–9) | 9 (5–10) | 0.0153* |
| Umbilical artery pH | 7.29 (7.15–7.38) | 7.21 (6.99–7.39) | 0.08 |
| NICU admission | 14(30%) | 3 (6.7%) | 0.0019* |
| Respiratory ventilator treatment | 8(17%) | 0 (0%) | 0.0018* |
| NAS | 7 (15%) | 1 (2.2%) | 0.0148* |
| Congenital Anomalies | 2 (4.3%) | 2 (4.4%) | 0.49 |
median (range) or number (%).
LFD: large-for-date, SGA: small-for-gestational age, NICU: neonatal intensive care unit, NAS: neonatal abstinence syndrome, CYP: cytochrome P450.
* p < 0.05.
Pregnant women taking two or more psychotropic drugs into two groups: those with CYP2D6 inhibition (+) and those without [CYP2D6 inhibition (-)].