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. 2025 Aug 22;15:30977. doi: 10.1038/s41598-025-16890-w

Table 2.

Demographics and clinicopathological characteristics of patients with esophageal carcinoma.

Characteristics All patients (n = 1542) Training cohort (N = 1116) Validation cohort (N = 426) P value
Number % Number % Number %
Sex
  Male 1288 83.5 931 83.4 357 83.8 0.857
  Female 254 16.5 185 16.6 69 16.2
Race
  White 1274 82.6 923 82.7 351 82.4 0.885
  Unwhite 268 17.4 193 17.3 75 17.6
Age
  < 65 years 877 56.9 630 56.5 247 58.0 0.588
  ≥ 65 years 665 43.1 486 43.5 179 42.0
Marriage
  Married 861 55.8 627 56.2 234 54.9 0.658
  Unmarried 681 44.2 489 43.8 192 45.1
Chemotherapy
  None 478 31.0 351 31.5 127 29.8 0.534
  Yes 1064 69.0 765 68.5 299 70.2
Radiotherapy
  None 771 50 561 50.3 210 49.3 0.733
  Yes 771 50 555 49.7 216 50.7
Histology
  Adenocarcinoma 1032 66.9 751 67.3 281 66.0 0.619
  Non- adenocarcinoma 510 33.1 365 32.7 145 34.0
Primary site
  Cervical/Upper 61 4.0 40 3.6 21 4.9 0.058
  Thoracic/middle 279 18.1 201 18.0 78 18.3
  Abdominal/lower 1119 72.6 805 72.1 314 73.7
  Overlapping 83 5.4 70 6.3 13 3.1
Surgery
  None 1459 94.6 1054 94.4 405 95.1 0.626
  Yes 83 5.4 62 5.6 21 4.9
Grade
  I + II 552 35.8 401 35.9 151 35.4 0.859
  III + IV 990 64.2 715 64.1 275 64.6
T Stage
  T1 414 26.8 295 26.4 119 27.9 0.620
  T2 84 5.4 66 5.9 18 4.2
  T3 390 25.3 285 25.5 105 24.6
  T4 399 25.9 291 26.1 108 25.4
  Tx 255 16.5 179 16.0 76 17.8
N Stage
  N0 417 27.0 299 26.8 118 27.7 0.684
  N1 998 64.7 721 64.6 277 65.0
  Nx 127 8.2 96 8.6 31 7.3
M Stage
  M1a 74 4.8 51 4.6 23 5.4 0.496
  M1b 1468 95.2 1065 95.4 403 94.6
Vital status
  Alive 34 2.2 24 2.2 10 2.3 0.814
  Death 1508 97.8 1092 97.8 416 97.7