Table 4.
The effects of PEG-rhG-CSF and rhG-CSF on long-term hematopoietic reconstitution and immune reconstitution at 6 months after ASCT.
| PEG-rhG-CSF (n = 31) | rhG-CSF (n = 35) | p value | |
|---|---|---|---|
|
ANC, × 109/L (range) Hemoglobin level, g/L (range) PLTc, × 109/L (range) |
2.9 (1.3–5.3) 127.3 (91–169) 153.1 (86–288) |
3.1 (1.6–5.0) 124.7 (65–155) 141.9 (36–233) |
0.386 0.586 0.397 |
| Total lymphocyte count, /ul (range) | 1082 (986.6–1215) | 1162 (1013–1318) | 0.397 |
| CD4 + lymphocyte count, /ul (range) | 217.7 (106–313.7) | 344.4 (170–549.2) | 0.313 |
| CD8 + lymphocyte count, /ul (range) | 509 (250.5–668.5) | 598.4 (451.3–769.7) | 0.498 |
| CD19 + lymphocyte count, /ul (range) | 178.1 (5.5–345.5) | 188.9 (80.2–386.4) | 0.930 |
| CD3 + CD56 + lymphocyte count, /ul (range) | 102.3 (5.3–167.2) | 306.5 (34.3–955) | 0.391 |
| Immunoglobulin G, g/L (range) | 9.6 (6.9–12.3) | 11.0 (4.6–35.8) | 0.686 |
| Immunoglobulin A, g/L (range) | 1.1 (0.3–2.1) | 0.8 (0–1.6) | 0.188 |
| Immunoglobulin M, g/L (range) | 0.5 (0.2–1.2) | 0.6 (0–2.1) | 0.602 |
ASCT, Autologous hematopoietic stem cell transplantation; PEG-rhG-CSF, Polyethylene glycolized recombinant human granulocyte-stimulating factor; rhG-CSF, Recombinant human granulocyte-stimulating factor; ANC, Absolute neutrophil count; LLN, Lower limit of normal; PLTc, Platelet count.