Table 1.

Predicted LRBA interactors by computational predictions.

N°	Gen	Protein code	Protein	Function	Database
1	CTLA4	P16410	Cytotoxic T-lymphocyte associated protein	Inhibitory receptor acting as a major negative regulator of T-cell responses	STRING
2	DCAF12L1	Q5VU92	DDB1- and CUL4-associated factor 12-like protein 1	Unknown	FuncBase
3	DCAF12L2	Q5VW00	DDB1- and CUL4-associated factor 12-like protein 2	Unknown	FuncBase
4	DCAF8L2	P0C7V8	DDB1- and CUL4-associated factor 8-like protein 2	Unknown	FuncBase
5	DOCK5	Q9H7D0	Dedicator of cytokinesis protein 5	Epithelial cell migration	FuncBase
6	DOCK8	Q8NF50	Dedicator of cytokinesis protein 8	Migration	STRING
7	FBXW7	Q969H0	F-Box and WD repeat domain containing 7	Ubiquitination and subsequent proteasomal degradation of target proteins	STRING
8	FBXW10	Q5XX13	F-box/WD repeat-containing protein 10	Ubiquitination and subsequent proteasomal degradation of target proteins	FuncBase
9	GNB1L	Q9BYB4	Guanine nucleotide-binding protein subunit beta-like protein 1	Intracellular signal transduction	FuncBase
10	IFT80	Q9P2H3	Intraflagellar transport protein 80 homolog	Development and maintenance of motile and sensory cilia	FuncBase
11	KIAA1875	A6NE52	WD repeat-containing protein 97	Generation of catalytic spliceosome	FuncBase
12	KIF21A	Q7Z4S6	Kinesin-like protein KIF21A	Microtubule-based movement	FuncBase
13	LRRK2	Q5S007	Leucine-rich repeat serine/threonine-protein kinase	Autophagy through the CaMKK/AMPK	FuncBase
14	LYST	Q99698	Lysosomal-trafficking regulator	Sorting endosomal resident proteins into late multivesicular endosomes	FuncBase
15	NBEAL1	Q6ZS30	Neurobeachin-like protein 1	Phospholipid binding	FuncBase
16	NSMAF	Q92636	Protein FAN	Ceramide metabolic process	FuncBase
17	NUP214	P35658	Nuclear pore complex protein Nup214	Nuclear export signal receptor activity	FuncBase
18	PIK3R4	Q99570	Phosphoinositide 3-kinase regulatory subunit 4	Macroautophagy and late endosome to vacuole transport	FuncBase STRING
19	PRKACA	P17612	Protein kinase cAMP-activated catalytic subunit alpha	Phosphorylation of substrates in the cytoplasm and the nucleus	STRING
20	PRKACB	P22694	Protein kinase cAMP-activated catalytic subunit beta	Phosphorylation of substrates in the cytoplasm and the nucleus	STRING
21	PRKACG	P22612	Protein kinase cAMP-activated catalytic subunit gamma	Phosphorylation of substrates in the cytoplasm and the nucleus	STRING
22	STXBP2	Q15833	Syntaxin binding protein 2	Intracellular vesicle trafficking and vesicle fusion with membranes	STRING
23	TLE6	Q9H808	Transducin-like enhancer protein 6	Positive regulation of neuron differentiation	FuncBase
24	TNFRSF1B	P20333	TNF receptor superfamily member 1B	Calcineurin- dependent activation of NF-AT, NF-kappa-B and AP-1	STRING
25	TTC7A	Q9ULT0	Tetratricopeptide repeat domain 7A	Regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis	STRING
26	VPS8	Q8N3P4	Vacuolar protein sorting-associated protein 8 homolog	Endosomal vesicle fusion	FuncBase
27	VPS11	Q9H270	Vacuolar protein sorting-associated protein 11 homolog	Vesicle-mediated protein trafficking	FuncBase
28	WDR88	Q6ZMY6	WD repeat-containing protein 88	Unknown	FuncBase
29	WDFY3	Q8IZQ1	WD repeat- and FYVE-containing protein 3	Aggrephagy	FuncBase
30	WDR46	O15213	WD repeat-containing protein 46	Scaffold component of the nucleolar structure	FuncBase
31	WDR87	Q6ZQQ6	WD repeat-containing protein 87	Unknown	FuncBase

List of the 31 potential LRBA interactors identified by FuncBase and/or STRING. Proteins are listed alphabetically. Proteins highlighted in bold were selected for validation by co-IP or PLA shown in Fig. 1 or EV1.