Table 2.

Rat PK parameters

		1E4	SAR
	Unit
Serum AUClast	hr × mg/mL	40.5	47.8
CSF AUClast	hr × mg/mL	0.03	0.08
Brain AUClast	hr × mg/mL	0.015	0.08
CSF AUClast/Serum AUClast	%	0.08	0.17
Brain AUClast/Serum AUClast	%	0.04	0.18

AUC_0-τ values estimated from non-compartmental analysis of mean serum, CSF and brain profiles following an i.v. bolus administration of 1E4 or SAR446159 to naïve rats. AUC_last represents area under the plasma concentration time curve from time zero to the last measurement.

AUClast: area under the drug concentration time curve from time = 0 to last measured concentration.