Table 3.

NHP PK parameters

		1E4		SAR446159
		(mg/kg)		(mg/kg)
		30	100	11.7	35.1	117
	Unit
Serum AUClast	hr × mg/mL	80.3	336	31.7	77.6	458
CSF AUClast	hr × mg/mL	0.10	0.32	0.14	0.31	0.95
Brain AUClast	hr × mg/mL	0.01	0.07	0.06	0.20	0.77
CSF AUClast/Serum AUClast	%	0.12	0.09	0.44	0.40	0.21
Brain AUClast/Serum AUClast	%	0.02	0.02	0.18	0.26	0.17

AUC_0-τ values estimated from non-compartmental analysis of mean serum, CSF, and brain profiles following an i.v. bolus administration of 1E4 and SAR446159 to naïve NHPs. AUC_last represents area under the plasma concentration time curve from time zero to the last measurement.

AUClast: area under the drug concentration time curve from time = 0 to last measured concentration.