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. 2025 Aug 22;16:7811. doi: 10.1038/s41467-025-63040-x

Fig. 1. Schematic illustration of dual-key cooperatively activated DNA regulator for precise regulation of mitochondria-lysosome interactions.

Fig. 1

After cellular internalization, the mitochondria-lysosome interaction regulator (DK-MLIR) binds mitochondria via TPP moiety. Then the DK-MLIR was cooperatively activated by light and endogenous glutathione (GSH) to form CD63 aptamer for lysosomal targeting and mitochondria-lysosome interactions regulation, resulting in mitochondrial fission and autophagy.