Table 1.

Table of model parameters

Kinetic parameter	Expression	Parameter	Value	Sourcea
$k_{\mathrm{on}},k_{\mathrm{on}}^{\prime }$	${p_{0}D}_{\mathrm{D}}{R}_{\mathrm{C}}$	$p_0$	2 × 1018 m−3	this study
$k_{\mathrm{off}}$	$p_0^{\prime }{k}_{\mathrm{on}}$	$p_0^{\prime }$	0.1	this study
$k_1$	$p_1$	$p_1$	0.0025 s−1	Fig. 2F
$k_2$	$p_2/R_{\mathrm{C}}$	$p_2$	3.33 × 10−9 m s−1	Fig. 2F
$k_3$	$p_3{R_{\mathrm{C}}}^{0.5}$	$p_3$	50.265 m−0.5 s−1	this study
$k_4$	$k_{\mathrm{on}}{k}_3{k}_6/\left(k_5{k}_{\mathrm{off}}\right)$			detailed balance
$k_5$	${p_5{R}_{\mathrm{C}}}^2{k}_3$	$p_5$	5 × 1012 m−2	this study
$k_6$	${p_{6}k}_{\mathrm{off}}$	$p_6$	10−1 to 10−4	manually set
$v_{\mathrm{C}}$	$p_{\mathrm{v}}/R_{\mathrm{C}}$	$p_{\mathrm{v}}$	3 × 10−13 m2 s−1	Fig. 3F

^aAll parameters in the model were either estimated or defined in this study. Specifically, $k_1$, $k_2$, and $v_{\mathrm{C}}$ were inferred from experimental measurements; $k_{\mathrm{on}}^{\prime }$ and $k_4$ were derived based on detailed balance; $k_6$ was manually set; and all remaining parameters were estimated by fitting simulation results.