Table 2.
Multivariate Mendelian randomization (MVMR) analysis to adjust metabolic factors or diseases.
| GWAS ID.exposure | Traits.exposure | N snp | B | SE | P |
|---|---|---|---|---|---|
| BMI adjusting lipid profiles | |||||
| ieu-b-40 | BMI | 135 | – 4.86E-02 | 1.92E-02 | 1.14E-02* |
| ebi-a-GCST90025953 | TC levels | 40 | 2.14E-01 | 1.84E-01 | 2.44E-01 |
| ieu-b-109 | HDL cholesterol | 55 | – 8.12E-02 | 6.47E-02 | 2.09E-01 |
| ieu-b-110 | LDL cholesterol | 35 | – 1.98E-01 | 1.72E-01 | 2.48E-01 |
| ieu-b-111 | Triglycerides | 34 | – 4.40E-02 | 3.95E-02 | 2.65E-01 |
| BMI adjusting type 2 diabetes | |||||
| ieu-b-40 | BMI | 387 | – 2.76E-02 | 1.15E-02 | 1.67E-02* |
| ebi-a-GCST006867 | Type 2 diabetes | 57 | – 3.34E-03 | 5.07E-03 | 5.10E-01 |
| BFP adjusting lipid profiles | |||||
| ukb-b-8909 | BFP | 103 | – 7.92E-02 | 2.43E-02 | 1.10E-03* |
| ebi-a-GCST90025953 | TC levels | 94 | – 7.67E-03 | 1.85E-02 | 6.79E-01 |
| ieu-b-109 | HDL cholesterol | 116 | 7.99E-03 | 1.38E-02 | 5.62E-01 |
| ieu-b-110 | LDL cholesterol | 78 | 2.09E-02 | 2.21E-02 | 3.45E-01 |
| ieu-b-111 | Triglycerides | 98 | 1.59E-02 | 1.46E-02 | 2.73E-01 |
| BFP adjusting type 2 diabetes | |||||
| ukb-b-8909 | BFP | 261 | – 6.79E-02 | 1.72E-02 | 8.13E-05* |
| ebi-a-GCST006867 | Type 2 diabetes | 70 | – 3.40E-03 | 4.99E-03 | 4.96E-01 |
| WC adjusting lipid profiles | |||||
| ukb-b-9405 | WC | 73 | – 3.56E-02 | 2.47E-02 | 1.49E-01 |
| ebi-a-GCST90025953 | TC levels | 91 | – 7.25E-03 | 1.97E-02 | 7.12E-01 |
| ieu-b-109 | HDL cholesterol | 118 | 4.19E-03 | 1.47E-02 | 7.75E-01 |
| ieu-b-110 | LDL cholesterol | 77 | 3.03E-02 | 2.35E-02 | 1.98E-01 |
| ieu-b-111 | Triglycerides | 102 | 1.64E-02 | 1.54E-02 | 2.88E-01 |
| WC adjusting type 2 diabetes | |||||
| ukb-b-9405 | WC | 253 | – 3.25E-02 | 1.59E-02 | 4.12E-02* |
| ebi-a-GCST006867 | Type 2 diabetes | 71 | 4.13E-05 | 5.29E-03 | 9.94E-01 |
| WHR adjusting lipid profiles | |||||
| ebi-a-GCST90025996 | WHR | 115 | – 1.08E-02 | 1.66E-02 | 5.14E-01 |
| ebi-a-GCST90025953 | TC levels | 92 | – 3.38E-02 | 6.17E-02 | 5.85E-01 |
| ieu-b-109 | HDL cholesterol | 119 | 1.57E-02 | 2.36E-02 | 5.05E-01 |
| ieu-b-110 | LDL cholesterol | 73 | 5.57E-02 | 6.03E-02 | 3.56E-01 |
| ieu-b-111 | Triglycerides | 111 | 2.46E-02 | 1.73E-02 | 1.56E-01 |
| WHR adjusting type 2 diabetes | |||||
| ebi-a-GCST90025996 | WHR | 154 | 1.89E-03 | 1.53E-02 | 9.02E-01 |
| ebi-a-GCST006867 | Type 2 diabetes | 46 | – 2.71E-03 | 6.01E-03 | 6.52E-01 |
Nsnp, number of SNPs; B, causal effect estimation; BMI, body mass index; TC, total cholesterol; HDL, high density lipoprotein; LDL, low density lipoprotein; BFP, body fat percentage; WC, waist circumference; WHR, waist-hip ratio.