Table 1.

Genome stability of Metavac®-RSV produced in Vero cells

CDS	Nucleic			Codon		Amino acid			Alternative frequency
Name	Position(a)	Ref	Alt	Ref	Alt	Position(b)	Ref	Alt	P + 1	P + 4 (c)	P + 6 (c)
HMPV-F	4694	A	G	GAA	GGA	294	E	G	-	0.12	0.25
	5115	G	T	CAG	CAT	434	Q	H	-	0.09	0.19
	5211	C	A	AGC	AGA	466	S	R	-	-	0.07
	5365	A	G	AAG	GAG	518	K	E	-	-	0.04
RSV-F	5668	A	G	AAG	AGG	65	K	R	-	-	0.07
	7126	A	C	AAG	ACG	551	K	T	-	-	0.04
	7199	A	T	TAA	TAT	575	*	YLIKNKVN*	0.09	0.19	0.24

List of single non-synonymous mutations identified in genes encoding sequence (CDS) for F proteins of Metavac®-RSV. Table details the reference base (“Ref”) and the variant base (“Alt”) at that specific nucleotide or amino acid position that represent mutations over a minimum frequency of 0.03 and short indels with a minimum frequency of 0.1.

^aStarting from the beginning of Metavac®-RSV genome.

^bFirst position is the start codon of each protein sequence.

^cMean frequency of two independent lineages.